                               SEQUENCE LISTING

<110> DANISCO US INC., GENENCOR DIVISION
 
<120> ALPHA-AMYLASE VARIANTS WITH ALTERED PROPERTIES

<130> 48452-0028-00-WO

<140>
<141>

<150> 61/059,411
<151> 2008-06-06

<150> 61/041,075
<151> 2008-03-31

<150> 61/026,579
<151> 2008-02-06

<150> 60/985,619
<151> 2007-11-05

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 515
<212> PRT
<213> Geobacillus stearothermophilus

<400> 1
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515 


<210> 2
<211> 486
<212> PRT
<213> Geobacillus stearothermophilus

<400> 2
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr 
                485     


<210> 3
<211> 515
<212> PRT
<213> Geobacillus stearothermophilus

<400> 3
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ala Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515 


<210> 4
<211> 515
<212> PRT
<213> Geobacillus stearothermophilus

<400> 4
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Gln Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515 


<210> 5
<211> 515
<212> PRT
<213> Geobacillus stearothermophilus

<400> 5
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Glu Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515 


<210> 6
<211> 485
<212> PRT
<213> Bacillus sp. 707

<400> 6
His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Asn Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Ala Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Thr Gly Glu Tyr Thr Ile Glu Ala Trp Thr Arg Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Arg Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly His Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Gln Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Asn Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Ser His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Arg Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Lys 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Ser Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Ser Asp Ile Thr Gly Asn Arg Thr Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210> 7
<211> 483
<212> PRT
<213> Bacillus sp. 707

<400> 7
Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn Arg Val 
        115                 120                 125             


Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His Phe Pro 
    130                 135                 140                 


Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu Leu Gln 
    210                 215                 220                 


Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ser 
305                 310                 315                 320 


Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His Lys Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala Gln His 
385                 390                 395                 400 


Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile Asn Ser 
    450                 455                 460                 


Glu Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Arg 
            


<210> 8
<211> 483
<212> PRT
<213> Bacillus licheniformis

<400> 8
Ala Asn Leu Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Arg Arg Leu Gln Asn Asp Ser Ala Tyr Leu 
            20                  25                  30          


Ala Glu His Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Thr Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Gly Glu Leu Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Ala Thr 
            100                 105                 110         


Glu Asp Val Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn Arg Val 
        115                 120                 125             


Ile Ser Gly Glu His Leu Ile Lys Ala Trp Thr His Phe His Phe Pro 
    130                 135                 140                 


Gly Arg Gly Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe 
145                 150                 155                 160 


Asp Gly Thr Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys 
                165                 170                 175     


Phe Gln Gly Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Ala Ala Glu Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu Leu Gln 
    210                 215                 220                 


Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Asn His Val Arg Glu Lys Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Asn Phe Asn His Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Tyr Gln Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Lys Leu Leu Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ser 
305                 310                 315                 320 


Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His Lys Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala Gln His 
385                 390                 395                 400 


Asp Tyr Phe Asp His His Asp Ile Val Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Val Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ala Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp His Asp Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile Asn Ser 
    450                 455                 460                 


Glu Gly Trp Gly Glu Phe His Val Asn Gly Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Arg 
            


<210> 9
<211> 483
<212> PRT
<213> Bacillus amyloliquefaciens

<400> 9
Val Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Thr Pro Asn Asp 
1               5                   10                  15      


Gly Gln His Trp Lys Arg Leu Gln Asn Asp Ala Glu His Leu Ser Asp 
            20                  25                  30          


Ile Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Leu Ser 
        35                  40                  45              


Gln Ser Asp Asn Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu 
    50                  55                  60                  


Phe Gln Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Ser Glu 
65                  70                  75                  80  


Leu Gln Asp Ala Ile Gly Ser Leu His Ser Arg Asn Val Gln Val Tyr 
                85                  90                  95      


Gly Asp Val Val Leu Asn His Lys Ala Gly Ala Asp Ala Thr Glu Asp 
            100                 105                 110         


Val Thr Ala Val Glu Val Asn Pro Ala Asn Arg Asn Gln Glu Thr Ser 
        115                 120                 125             


Glu Glu Tyr Gln Ile Lys Ala Trp Thr Asp Phe Arg Phe Pro Gly Arg 
    130                 135                 140                 


Gly Asn Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly 
145                 150                 155                 160 


Ala Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile Phe Lys Phe Arg 
                165                 170                 175     


Gly Glu Gly Lys Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp Val 
        195                 200                 205             


Val Ala Glu Thr Lys Lys Trp Gly Ile Trp Tyr Ala Asn Glu Leu Ser 
    210                 215                 220                 


Leu Asp Gly Phe Arg Ile Asp Ala Ala Lys His Ile Lys Phe Ser Phe 
225                 230                 235                 240 


Leu Arg Asp Trp Val Gln Ala Val Arg Gln Ala Thr Gly Lys Glu Met 
                245                 250                 255     


Phe Thr Val Ala Glu Tyr Trp Gln Asn Asn Ala Gly Lys Leu Glu Asn 
            260                 265                 270         


Tyr Leu Asn Lys Thr Ser Phe Asn Gln Ser Val Phe Asp Val Pro Leu 
        275                 280                 285             


His Phe Asn Leu Gln Ala Ala Ser Ser Gln Gly Gly Gly Tyr Asp Met 
    290                 295                 300                 


Arg Arg Leu Leu Asp Gly Thr Val Val Ser Arg His Pro Glu Lys Ala 
305                 310                 315                 320 


Val Thr Phe Val Glu Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu 
                325                 330                 335     


Ser Thr Val Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu 
            340                 345                 350         


Thr Arg Glu Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly 
        355                 360                 365             


Thr Lys Gly Thr Ser Pro Lys Glu Ile Pro Ser Leu Lys Asp Asn Ile 
    370                 375                 380                 


Glu Pro Ile Leu Lys Ala Arg Lys Glu Tyr Ala Tyr Gly Pro Gln His 
385                 390                 395                 400 


Asp Tyr Ile Asp His Pro Asp Val Ile Gly Trp Thr Arg Glu Gly Asp 
                405                 410                 415     


Ser Ser Ala Ala Lys Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Arg Met Tyr Ala Gly Leu Lys Asn Ala Gly Glu Thr 
        435                 440                 445             


Trp Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Lys Ile Gly Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe His Val Asn Asp Gly Ser Val Ser Ile Tyr 
465                 470                 475                 480 


Val Gln Lys 
            


<210> 10
<211> 485
<212> PRT
<213> Bacillus sp. 707

<400> 10
His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Ser Asp Ala Ser 
            20                  25                  30          


Asn Leu Lys Asp Lys Gly Ile Ser Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Ala Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Asn Gln Leu Gln Ala Ala Val Asn Ala Leu Lys Ser Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Met Val Arg Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Val Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Gly Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Gly Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Ile Asn His Val Arg Ser Ala 
                245                 250                 255     


Thr Gly Lys Asn Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Ile Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Arg Gln Ile Phe Asn Gly Thr Val Val Gln Arg 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Glu Glu Ala Leu Glu Ser Phe Val Glu Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Thr Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ala Met Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Lys Tyr Ala Tyr Gly Arg 
385                 390                 395                 400 


Gln Asn Asp Tyr Leu Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Ala His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Ala Gly Gly Asn Lys Trp Met Phe Val Gly Arg Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Thr Asp Ile Thr Gly Asn Arg Ala Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Asn Lys 
                485 


<210> 11
<211> 485
<212> PRT
<213> Bacillus halmapalus

<400> 11
His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Asp Asp Ala Ser 
            20                  25                  30          


Asn Leu Arg Asn Arg Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Glu Ser Ala Ile His Ala Leu Lys Asn Asn Gly 
                85                  90                  95      


Val Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Asn Val Leu Ala Val Glu Val Asn Pro Asn Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Asp Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Asp Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Gln Ser Arg Gln Phe Gln Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Asp Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Val Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Asn Glu Leu Arg Arg Trp Gly Glu Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Asn Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Phe Thr Arg Asp Trp Leu Thr His Val Arg Asn Ala 
                245                 250                 255     


Thr Gly Lys Glu Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Asn Lys Thr Asn Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Asn Ser Gly 
    290                 295                 300                 


Gly Asn Tyr Asp Met Ala Lys Leu Leu Asn Gly Thr Val Val Gln Lys 
305                 310                 315                 320 


His Pro Met His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Gly Glu Ser Leu Glu Ser Phe Val Gln Glu Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Ile Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Ser Val Pro Ala Met Lys Ala 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Glu Ala Arg Gln Asn Phe Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asn Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asn Thr Thr His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Glu Lys Trp Met Tyr Val Gly Gln Asn Lys Ala Gly 
        435                 440                 445             


Gln Val Trp His Asp Ile Thr Gly Asn Lys Pro Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Ala Asn Phe Ser Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Lys Arg 
                485 


<210> 12
<211> 485
<212> PRT
<213> Bacillus sp.

<400> 12
His His Asn Gly Thr Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His 
1               5                   10                  15      


Leu Pro Asn Asp Gly Asn His Trp Asn Arg Leu Arg Asp Asp Ala Ala 
            20                  25                  30          


Asn Leu Lys Ser Lys Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Gln Asn Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Arg Ser Gln Leu Gln Gly Ala Val Thr Ser Leu Lys Asn Asn Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Met Val Asn Ala Val Glu Val Asn Arg Ser Asn Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Glu Tyr Thr Ile Glu Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Asn Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Thr Asp Trp Asp Gln Ser Arg Gln Leu Gln Asn Lys 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Thr Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ile Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Ile Asn Glu Leu Arg Asn Trp Gly Val Trp Tyr 
    210                 215                 220                 


Thr Asn Thr Leu Asn Leu Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Tyr Ser Tyr Thr Arg Asp Trp Leu Thr His Val Arg Asn Thr 
                245                 250                 255     


Thr Gly Lys Pro Met Phe Ala Val Ala Glu Phe Trp Lys Asn Asp Leu 
            260                 265                 270         


Ala Ala Ile Glu Asn Tyr Leu Asn Lys Thr Ser Trp Asn His Ser Val 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Leu Tyr Asn Ala Ser Asn Ser Gly 
    290                 295                 300                 


Gly Tyr Phe Asp Met Arg Asn Ile Leu Asn Gly Ser Val Val Gln Lys 
305                 310                 315                 320 


His Pro Ile His Ala Val Thr Phe Val Asp Asn His Asp Ser Gln Pro 
                325                 330                 335     


Gly Glu Ala Leu Glu Ser Phe Val Gln Ser Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Leu Ile Leu Thr Arg Glu Gln Gly Tyr Pro Ser Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Thr His Gly Val Pro Ser Met Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Gln Ala Arg Gln Thr Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Phe Asp His His Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Asp Ser Ser His Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Asn Lys Trp Met Tyr Val Gly Lys His Lys Ala Gly 
        435                 440                 445             


Gln Val Trp Arg Asp Ile Thr Gly Asn Arg Ser Gly Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Asn Phe Thr Val Asn Gly Gly Ala Val Ser 
465                 470                 475                 480 


Val Trp Val Lys Gln 
                485 


<210> 13
<211> 480
<212> PRT
<213> Bacillus sp.

<400> 13
Asp Gly Leu Asn Gly Thr Met Met Gln Tyr Tyr Glu Trp His Leu Glu 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Asn Arg Leu His Asp Asp Ala Ala Ala Leu 
            20                  25                  30          


Ser Asp Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Asn Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Ala Gln Leu Glu Arg Ala Ile Gly Ser Leu Lys Ser Asn Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Met Gly Ala Asp Phe Thr 
            100                 105                 110         


Glu Ala Val Gln Ala Val Gln Val Asn Pro Thr Asn Arg Trp Gln Asp 
        115                 120                 125             


Ile Ser Gly Ala Tyr Thr Ile Asp Ala Trp Thr Gly Phe Asp Phe Ser 
    130                 135                 140                 


Gly Arg Asn Asn Ala Tyr Ser Asp Phe Lys Trp Arg Trp Phe His Phe 
145                 150                 155                 160 


Asn Gly Val Asp Trp Asp Gln Arg Tyr Gln Glu Asn His Ile Phe Arg 
                165                 170                 175     


Phe Ala Asn Thr Asn Trp Asn Trp Arg Val Asp Glu Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Leu Gly Ser Asn Ile Asp Phe Ser His Pro Glu Val 
        195                 200                 205             


Gln Asp Glu Leu Lys Asp Trp Gly Ser Trp Phe Thr Asp Glu Leu Asp 
    210                 215                 220                 


Leu Asp Gly Tyr Arg Leu Asp Ala Ile Lys His Ile Pro Phe Trp Tyr 
225                 230                 235                 240 


Thr Ser Asp Trp Val Arg His Gln Arg Asn Glu Ala Asp Gln Asp Leu 
                245                 250                 255     


Phe Val Val Gly Glu Tyr Trp Lys Asp Asp Val Gly Ala Leu Glu Phe 
            260                 265                 270         


Tyr Leu Asp Glu Met Asn Trp Glu Met Ser Leu Phe Asp Val Pro Leu 
        275                 280                 285             


Asn Tyr Asn Phe Tyr Arg Ala Ser Gln Gln Gly Gly Ser Tyr Asp Met 
    290                 295                 300                 


Arg Asn Ile Leu Arg Gly Ser Leu Val Glu Ala His Pro Met His Ala 
305                 310                 315                 320 


Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Glu Ser Leu Glu 
                325                 330                 335     


Ser Trp Val Ala Asp Trp Phe Lys Pro Leu Ala Tyr Ala Thr Ile Leu 
            340                 345                 350         


Thr Arg Glu Gly Gly Tyr Pro Asn Val Phe Tyr Gly Asp Tyr Tyr Gly 
        355                 360                 365             


Ile Pro Asn Asp Asn Ile Ser Ala Lys Lys Asp Met Ile Asp Glu Leu 
    370                 375                 380                 


Leu Asp Ala Arg Gln Asn Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe 
385                 390                 395                 400 


Asp His Trp Asp Val Val Gly Trp Thr Arg Glu Gly Ser Ser Ser Arg 
                405                 410                 415     


Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asn Gly Pro Gly Gly Ser 
            420                 425                 430         


Lys Trp Met Tyr Val Gly Arg Gln Asn Ala Gly Gln Thr Trp Thr Asp 
        435                 440                 445             


Leu Thr Gly Asn Asn Gly Ala Ser Val Thr Ile Asn Gly Asp Gly Trp 
    450                 455                 460                 


Gly Glu Phe Phe Thr Asn Gly Gly Ser Val Ser Val Tyr Val Asn Gln 
465                 470                 475                 480 


<210> 14
<211> 480
<212> PRT
<213> Bacillus sp.

<400> 14
Asp Gly Leu Asn Gly Thr Met Met Gln Tyr Tyr Glu Trp His Leu Glu 
1               5                   10                  15      


Asn Asp Gly Gln His Trp Asn Arg Leu His Asp Asp Ala Glu Ala Leu 
            20                  25                  30          


Ser Asn Ala Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Tyr Lys Gly 
        35                  40                  45              


Asn Ser Gln Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu 
    50                  55                  60                  


Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys 
65                  70                  75                  80  


Ala Gln Leu Glu Arg Ala Ile Gly Ser Leu Lys Ser Asn Asp Ile Asn 
                85                  90                  95      


Val Tyr Gly Asp Val Val Met Asn His Lys Leu Gly Ala Asp Phe Thr 
            100                 105                 110         


Glu Ala Val Gln Ala Val Gln Val Asn Pro Ser Asn Arg Trp Gln Asp 
        115                 120                 125             


Ile Ser Gly Val Tyr Thr Ile Asp Ala Trp Thr Gly Phe Asp Phe Pro 
    130                 135                 140                 


Gly Arg Asn Asn Ala Tyr Ser Asp Phe Lys Trp Arg Trp Phe His Phe 
145                 150                 155                 160 


Asn Gly Val Asp Trp Asp Gln Arg Tyr Gln Glu Asn His Leu Phe Arg 
                165                 170                 175     


Phe Ala Asn Thr Asn Trp Asn Trp Arg Val Asp Glu Glu Asn Gly Asn 
            180                 185                 190         


Tyr Asp Tyr Leu Leu Gly Ser Asn Ile Asp Phe Ser His Pro Glu Val 
        195                 200                 205             


Gln Glu Glu Leu Lys Asp Trp Gly Ser Trp Phe Thr Asp Glu Leu Asp 
    210                 215                 220                 


Leu Asp Gly Tyr Arg Leu Asp Ala Ile Lys His Ile Pro Phe Trp Tyr 
225                 230                 235                 240 


Thr Ser Asp Trp Val Arg His Gln Arg Ser Glu Ala Asp Gln Asp Leu 
                245                 250                 255     


Phe Val Val Gly Glu Tyr Trp Lys Asp Asp Val Gly Ala Leu Glu Phe 
            260                 265                 270         


Tyr Leu Asp Glu Met Asn Trp Glu Met Ser Leu Phe Asp Val Pro Leu 
        275                 280                 285             


Asn Tyr Asn Phe Tyr Arg Ala Ser Lys Gln Gly Gly Ser Tyr Asp Met 
    290                 295                 300                 


Arg Asn Ile Leu Arg Gly Ser Leu Val Glu Ala His Pro Ile His Ala 
305                 310                 315                 320 


Val Thr Phe Val Asp Asn His Asp Thr Gln Pro Gly Glu Ser Leu Glu 
                325                 330                 335     


Ser Trp Val Ala Asp Trp Phe Lys Pro Leu Ala Tyr Ala Thr Ile Leu 
            340                 345                 350         


Thr Arg Glu Gly Gly Tyr Pro Asn Val Phe Tyr Gly Asp Tyr Tyr Gly 
        355                 360                 365             


Ile Pro Asn Asp Asn Ile Ser Ala Lys Lys Asp Met Ile Asp Glu Leu 
    370                 375                 380                 


Leu Asp Ala Arg Gln Asn Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe 
385                 390                 395                 400 


Asp His Trp Asp Ile Val Gly Trp Thr Arg Glu Gly Thr Ser Ser Arg 
                405                 410                 415     


Pro Asn Ser Gly Leu Ala Thr Ile Met Ser Asn Gly Pro Gly Gly Ser 
            420                 425                 430         


Lys Trp Met Tyr Val Gly Gln Gln His Ala Gly Gln Thr Trp Thr Asp 
        435                 440                 445             


Leu Thr Gly Asn His Ala Ala Ser Val Thr Ile Asn Gly Asp Gly Trp 
    450                 455                 460                 


Gly Glu Phe Phe Thr Asn Gly Gly Ser Val Ser Val Tyr Val Asn Gln 
465                 470                 475                 480 


<210> 15
<211> 486
<212> PRT
<213> Geobacillus stearothermophilus

<400> 15
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu Phe Gly 
            180                 185                 190         


Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His Pro Glu 
        195                 200                 205             


Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn Thr Thr 
    210                 215                 220                 


Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser 
225                 230                 235                 240 


Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly Lys Pro 
                245                 250                 255     


Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys Leu His 
            260                 265                 270         


Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp Ala Pro 
        275                 280                 285             


Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala Phe Asp 
    290                 295                 300                 


Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro Thr Leu 
305                 310                 315                 320 


Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln Ala Leu 
                325                 330                 335     


Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile 
            340                 345                 350         


Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp Tyr Tyr 
        355                 360                 365             


Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile Asp Pro 
    370                 375                 380                 


Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His Asp Tyr 
385                 390                 395                 400 


Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Gly Thr Glu 
                405                 410                 415     


Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly 
            420                 425                 430         


Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val Phe Tyr 
        435                 440                 445             


Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser Asp Gly 
    450                 455                 460                 


Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp Val Pro 
465                 470                 475                 480 


Arg Lys Thr Thr Val Ser 
                485     


<210> 16
<211> 520
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" or " "

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Gly" or "Asn" or " "

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr" or "Leu" or "Val"

<220>
<221> misc_feature
<222> (4)..(5)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (25)..(25)
<223> /replace="Asn" or "Lys" or "Arg"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Asn" or "Gln" or "Arg" or "His"

<220>
<221> misc_feature
<222> (28)..(28)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Ser" or "Ala" or "Glu"

<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (37)..(37)
<223> /replace="Lys" or "His" or "Ile" or "Arg" or "Ala"

<220>
<221> misc_feature
<222> (37)..(37)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Gln" or "Glu"

<220>
<221> VARIANT
<222> (87)..(87)
<223> /replace="Ala" or "Ser" or "Asp" or "Gly" or "Arg"

<220>
<221> misc_feature
<222> (86)..(87)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (90)..(90)
<223> /replace="Thr" or "Lys" or "Gly" or "Asn" or "His"

<220>
<221> misc_feature
<222> (90)..(90)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (95)..(95)
<223> /replace="Asn" or "Arg"

<220>
<221> misc_feature
<222> (95)..(95)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (116)..(116)
<223> /replace="Met" or "Asp" or "Asn" or "Ala"

<220>
<221> misc_feature
<222> (116)..(116)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (118)..(118)
<223> /replace="Arg" or "Thr" or "Leu" or "Asn" or "Gln"

<220>
<221> misc_feature
<222> (118)..(118)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (134)..(134)
<223> /replace="Glu" or "Asp" or "Ala" or "Val"

<220>
<221> misc_feature
<222> (134)..(134)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (136)..(136)
<223> /replace="Thr" or "Leu"

<220>
<221> misc_feature
<222> (136)..(136)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (138)..(138)
<223> /replace="Glu" or "Lys" or "Asp"

<220>
<221> misc_feature
<222> (138)..(138)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (154)..(154)
<223> /replace="Asp" or "Asn"

<220>
<221> misc_feature
<222> (154)..(154)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (175)..(175)
<223> /replace=" "

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace="His" or "Glu" or "Asp" or "Thr" or " "

<220>
<221> misc_feature
<222> (183)..(183)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (215)..(215)
<223> /replace="Asn" or "Ala" or "Asp" or "Glu"

<220>
<221> misc_feature
<222> (215)..(215)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (222)..(222)
<223> /replace="Val" or "Thr" or "Ile" or "Glu" or "Ser"

<220>
<221> misc_feature
<222> (222)..(222)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Thr" or "Ala"

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (246)..(246)
<223> /replace="Thr" or "Leu"

<220>
<221> misc_feature
<222> (246)..(246)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (247)..(247)
<223> /replace="Pro" or "Ser"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Ala" or "Lys" or "Thr" or "Glu"

<220>
<221> misc_feature
<222> (256)..(256)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (260)..(260)
<223> /replace="Asn" or "Glu" or "Asp"

<220>
<221> misc_feature
<222> (260)..(260)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (269)..(269)
<223> /replace="Lys" or "Gln"

<220>
<221> misc_feature
<222> (269)..(269)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (270)..(270)
<223> /replace="Tyr" or "Asp"

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Gln" or "Asn" or "Asp"

<220>
<221> misc_feature
<222> (280)..(280)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (285)..(285)
<223> /replace="Thr" or "Glu"

<220>
<221> VARIANT
<222> (299)..(299)
<223> /replace="Asn" or "Ala" or "Arg"

<220>
<221> misc_feature
<222> (299)..(299)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (311)..(311)
<223> /replace="Asn" or "Lys" or "Arg" or "Gln"

<220>
<221> misc_feature
<222> (311)..(311)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (314)..(314)
<223> /replace="Asn" or "Asp" or "Arg"

<220>
<221> misc_feature
<222> (314)..(314)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="Gln" or "Ser" or "Glu"

<220>
<221> VARIANT
<222> (320)..(320)
<223> /replace="Arg" or "Lys" or "Ala"

<220>
<221> misc_feature
<222> (319)..(320)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (323)..(323)
<223> /replace="Ser" or "Leu" or "Glu" or "Met" or "Ile"

<220>
<221> VARIANT
<222> (324)..(324)
<223> /replace="His" or "Lys"

<220>
<221> misc_feature
<222> (323)..(324)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (346)..(346)
<223> /replace="Glu" or "Thr" or "Ser" or "Asp"

<220>
<221> misc_feature
<222> (346)..(346)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (361)..(361)
<223> /replace="Gln" or "Ser" or "Gly"

<220>
<221> misc_feature
<222> (361)..(361)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (365)..(365)
<223> /replace="Ser" or "Gln" or "Asn"

<220>
<221> misc_feature
<222> (365)..(365)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (379)..(379)
<223> /replace="Pro" or " "

<220>
<221> VARIANT
<222> (380)..(380)
<223> /replace="Lys" or " "

<220>
<221> VARIANT
<222> (381)..(381)
<223> /replace=" "

<220>
<221> VARIANT
<222> (394)..(394)
<223> /replace="Glu" or "Lys" or "Gln" or "Asp"

<220>
<221> misc_feature
<222> (394)..(394)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (398)..(398)
<223> /replace="Lys" or "Gln" or "Glu" or "Asn" or "Thr"

<220>
<221> misc_feature
<222> (398)..(398)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (411)..(411)
<223> /replace="His" or "Pro" or "Trp"

<220>
<221> misc_feature
<222> (411)..(411)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="Asn" or "Asp" or "Ser" or "Thr" or "Gly"

<220>
<221> misc_feature
<222> (421)..(421)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (449)..(449)
<223> /replace="Lys" or "Asn"

<220>
<221> misc_feature
<222> (449)..(449)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (452)..(452)
<223> /replace="Gln" or "Glu"

<220>
<221> misc_feature
<222> (452)..(452)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (476)..(476)
<223> /replace="Ser" or "His" or "Thr" or "Phe"

<220>
<221> misc_feature
<222> (476)..(476)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (487)..(487)
<223> /replace="Asn" or "Gln" or "Lys"

<220>
<221> misc_feature
<222> (487)..(487)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(497)
<223> /replace=" "

<220>
<221> VARIANT
<222> (498)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> VARIANT
<222> (518)..(518)
<223> /replace=" "

<220>
<221> VARIANT
<222> (519)..(519)
<223> /replace=" "

<220>
<221> VARIANT
<222> (520)..(520)
<223> /replace=" "

<220>
<221> misc_feature
<222> (489)..(520)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 16
His Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asn Asp Gly Gln His Trp Thr Arg Leu Ala Asn Asp Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Ile Pro Pro Ala Tyr 
        35                  40                  45              


Lys Gly Thr Ser Gln Ser Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Leu Leu Gln Ala Ile Gln Ala Leu His Ala Ala Gly 
                85                  90                  95      


Ile Gln Val Tyr Gly Asp Val Val Met Asn His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Asn Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Leu Asn Leu Asp Gly Phe Arg Leu Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Arg Asp Trp Leu Ser His Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Asn Asp Ile 
            260                 265                 270         


Gly Ala Leu Glu Asn Tyr Leu Thr Lys Thr Asn Trp Asn Met Ser Leu 
        275                 280                 285             


Phe Asp Val Pro Leu His Tyr Asn Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Ala Tyr Asp Met Arg Thr Leu Leu Thr Gly Thr Leu Val Lys Asp 
305                 310                 315                 320 


His Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Pro 
                325                 330                 335     


Gly Gln Ala Leu Glu Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Glu Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln Tyr Asn Gln Arg Glu Ile Pro Ser 
    370                 375                 380                 


Leu Lys Ser Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala 
385                 390                 395                 400 


Tyr Gly Thr Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp 
                405                 410                 415     


Thr Arg Glu Gly Val Thr Ser Lys Pro Asn Ser Gly Leu Ala Ala Leu 
            420                 425                 430         


Ile Thr Asp Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln 
        435                 440                 445             


His Ala Gly Lys Val Trp Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr 
    450                 455                 460                 


Val Thr Ile Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly 
465                 470                 475                 480 


Ser Val Ser Val Trp Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala 
                485                 490                 495     


Arg Pro Ile Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr 
            500                 505                 510         


Glu Pro Arg Leu Val Ala Trp Pro 
        515                 520 


<210> 17
<211> 39
<212> DNA
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 17
gtcaagcata ttaagttcnn sttttttcct gattggttg                            39


<210> 18
<211> 39
<212> DNA
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      oligonucleotide"


<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 18
caaccaatca ggaaaaaasn ngaacttaat atgcttgac                            39


<210> 19
<211> 87
<212> DNA
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      oligonucleotide"

<400> 19
atgaaacaac aaaaacggct ttacgcccga ttgctgacgc tgttatttgc gctcatcttc     60

ttgctgcctc attctgcagc ttcagca                                         87


<210> 20
<211> 29
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      peptide"

<400> 20
Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe 
1               5                   10                  15      


Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala Ser Ala 
            20                  25                  


<210> 21
<211> 486
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      polypeptide"

<400> 21
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Gln Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr 
                485     


<210> 22
<211> 517
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (1)..(5)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (19)..(19)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (19)..(19)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace="His"

<220>
<221> misc_feature
<222> (22)..(23)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (25)..(25)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (29)..(29)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (28)..(29)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (37)..(37)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (37)..(37)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (53)..(53)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (54)..(54)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (53)..(54)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (60)..(60)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (60)..(60)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (87)..(87)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (85)..(87)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (90)..(90)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (90)..(90)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (93)..(93)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (94)..(95)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (92)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (106)..(106)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (105)..(106)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (116)..(116)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (116)..(116)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (118)..(118)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (118)..(118)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (125)..(125)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (126)..(126)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (125)..(126)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (134)..(134)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (134)..(134)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (136)..(136)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (136)..(136)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (138)..(138)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (138)..(138)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (169)..(169)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (169)..(169)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (175)..(175)
<223> /replace=" "

<220>
<221> misc_feature
<222> (174)..(175)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace="His"

<220>
<221> misc_feature
<222> (183)..(183)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (215)..(215)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (215)..(215)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (222)..(222)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (222)..(222)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (228)..(229)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (246)..(246)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (247)..(247)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (246)..(247)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (251)..(251)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (251)..(251)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (256)..(256)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (260)..(260)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (260)..(260)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (263)..(263)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (263)..(263)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (269)..(269)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (270)..(270)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (269)..(270)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (273)..(273)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (273)..(274)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (276)..(276)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (276)..(276)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (280)..(280)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (284)..(284)
<223> /replace="Trp"

<220>
<221> VARIANT
<222> (285)..(285)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (286)..(286)
<223> /replace="His"

<220>
<221> misc_feature
<222> (284)..(286)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (291)..(291)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (291)..(291)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (295)..(295)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (296)..(296)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (295)..(297)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (299)..(299)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (299)..(299)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (306)..(306)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (306)..(306)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (311)..(311)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (311)..(311)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (313)..(313)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (314)..(314)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (315)..(315)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (313)..(315)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (320)..(320)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="His"

<220>
<221> misc_feature
<222> (319)..(321)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (324)..(324)
<223> /replace="His"

<220>
<221> misc_feature
<222> (324)..(324)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (335)..(335)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (335)..(335)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (337)..(337)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (338)..(338)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (337)..(338)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (341)..(341)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (341)..(341)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (346)..(346)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (346)..(346)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (355)..(355)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (356)..(356)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (355)..(356)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (360)..(360)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (361)..(361)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (360)..(361)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (365)..(365)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (365)..(365)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (376)..(376)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (378)..(378)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (391)..(391)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (391)..(391)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (394)..(394)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (395)..(395)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (394)..(395)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (400)..(400)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (400)..(400)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (402)..(402)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (402)..(402)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (408)..(408)
<223> /replace="His"

<220>
<221> VARIANT
<222> (409)..(409)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (408)..(409)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (418)..(418)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (418)..(418)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (420)..(420)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="His"

<220>
<221> misc_feature
<222> (420)..(421)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (423)..(423)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (423)..(423)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (428)..(428)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (428)..(428)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (434)..(434)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (434)..(434)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (446)..(446)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (446)..(446)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (449)..(449)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (449)..(449)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (452)..(452)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (452)..(452)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (460)..(460)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (460)..(460)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (471)..(471)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (471)..(471)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (473)..(473)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (473)..(473)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (484)..(484)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (484)..(484)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (486)..(486)
<223> /replace=" "

<220>
<221> VARIANT
<222> (487)..(488)
<223> /replace=" "

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> misc_feature
<222> (486)..(517)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 22
His Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Ile Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Ile Ser His Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Ala Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Ile His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Ala Phe Asp Met Arg Thr Ile Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Ser Leu Ala Val Thr Phe Val Asp Asn His Asp Ser Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Phe Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln His Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Ile Ile Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Phe Val Gly Lys Asn His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile 
                485                 490                 495     


Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg 
            500                 505                 510         


Leu Val Ala Trp Pro 
        515         


<210> 23
<211> 518
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (18)..(18)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (18)..(18)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (21)..(21)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="His"

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (24)..(24)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (27)..(27)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (27)..(27)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (31)..(31)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (31)..(32)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="His"

<220>
<221> misc_feature
<222> (35)..(36)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (52)..(52)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (52)..(52)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (59)..(59)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (59)..(59)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (69)..(69)
<223> /replace="His"

<220>
<221> misc_feature
<222> (69)..(69)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (83)..(83)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (84)..(84)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (83)..(86)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (89)..(89)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (89)..(89)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (91)..(91)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (91)..(91)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (94)..(94)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (95)..(95)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (94)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (104)..(104)
<223> /replace="Ile"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (104)..(105)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (115)..(115)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (115)..(115)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (117)..(117)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (117)..(117)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (122)..(122)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (122)..(122)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (128)..(128)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (129)..(129)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (128)..(129)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (133)..(133)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (135)..(135)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (135)..(135)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (137)..(137)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (137)..(137)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (141)..(141)
<223> /replace="His"

<220>
<221> misc_feature
<222> (141)..(141)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (143)..(143)
<223> /replace="His"

<220>
<221> misc_feature
<222> (143)..(143)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (149)..(149)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (149)..(149)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (153)..(153)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (153)..(153)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (157)..(157)
<223> /replace="His"

<220>
<221> misc_feature
<222> (157)..(157)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (164)..(164)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (164)..(164)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (173)..(173)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (173)..(173)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (179)..(179)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (180)..(180)
<223> /replace=" "

<220>
<221> VARIANT
<222> (181)..(181)
<223> /replace=" "

<220>
<221> misc_feature
<222> (179)..(181)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (190)..(190)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (191)..(191)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (190)..(191)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (206)..(206)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (206)..(206)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (213)..(213)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (212)..(213)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (217)..(217)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (217)..(217)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (220)..(220)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (220)..(220)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (223)..(223)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (225)..(226)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (244)..(244)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (245)..(245)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (244)..(245)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (249)..(249)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (249)..(249)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (253)..(253)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (254)..(254)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (253)..(254)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (258)..(258)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (258)..(258)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (267)..(267)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (268)..(268)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (267)..(268)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (271)..(271)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (272)..(272)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (271)..(272)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (274)..(274)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (278)..(278)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (278)..(278)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (282)..(282)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (283)..(283)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (284)..(284)
<223> /replace="His"

<220>
<221> misc_feature
<222> (282)..(284)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (289)..(289)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (289)..(289)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (293)..(293)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (294)..(294)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (293)..(294)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (297)..(297)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (300)..(300)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (301)..(301)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (300)..(301)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (309)..(309)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (309)..(309)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (312)..(312)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (313)..(313)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (312)..(313)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (317)..(317)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (318)..(318)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="His"

<220>
<221> misc_feature
<222> (317)..(319)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (322)..(322)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (321)..(322)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (333)..(333)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (333)..(333)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (339)..(339)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (339)..(339)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (341)..(341)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (341)..(341)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (343)..(343)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (344)..(344)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (343)..(344)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (358)..(358)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (359)..(359)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (358)..(359)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (363)..(363)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (363)..(363)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (369)..(369)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (369)..(369)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (372)..(372)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (373)..(373)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (374)..(374)
<223> /replace=" "

<220>
<221> VARIANT
<222> (375)..(375)
<223> /replace=" "

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace=" "

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (379)..(379)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (372)..(379)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (385)..(385)
<223> /replace="His"

<220>
<221> misc_feature
<222> (385)..(385)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (392)..(392)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (392)..(392)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (396)..(396)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (396)..(396)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (401)..(401)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (401)..(401)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (406)..(406)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (406)..(406)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (409)..(409)
<223> /replace="His"

<220>
<221> misc_feature
<222> (409)..(409)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (419)..(419)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (419)..(419)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (422)..(422)
<223> /replace="Val"

<220>
<221> VARIANT
<222> (423)..(423)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (424)..(424)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (421)..(424)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (440)..(440)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (440)..(440)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (447)..(447)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (447)..(447)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (450)..(450)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (451)..(451)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (450)..(451)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (462)..(462)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (462)..(462)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (464)..(464)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (464)..(464)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (474)..(474)
<223> /replace="His"

<220>
<221> misc_feature
<222> (474)..(474)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (485)..(485)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (485)..(485)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (487)..(487)
<223> /replace=" "

<220>
<221> VARIANT
<222> (488)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(497)
<223> /replace=" "

<220>
<221> VARIANT
<222> (498)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> VARIANT
<222> (518)..(518)
<223> /replace=" "

<220>
<221> misc_feature
<222> (487)..(518)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 23
Ala Ala Pro Phe Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn Asn 
            20                  25                  30          


Leu Ala Ser Leu Gly Ile Thr Ala Leu Trp Ile Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Ile 
                85                  90                  95      


Asn Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Ala 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ala Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr His Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met Asp His 
        195                 200                 205             


Pro Asp Val Val Thr Glu Ile Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser His Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe His Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Leu Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gly Asp Ser Gln Tyr Asn Ile Pro Ala Leu Lys 
    370                 375                 380                 


Ser Lys Ile Asp Pro Ile Leu Ile Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Val Ser Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ala Lys Trp Met Tyr Val Gly Lys Gln His Ala 
        435                 440                 445             


Gly Lys Val Phe His Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Thr 
    450                 455                 460                 


Ile Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Trp Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro 
                485                 490                 495     


Ile Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro 
            500                 505                 510         


Arg Leu Val Ala Trp Pro 
        515             


<210> 24
<211> 518
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace=" "

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (1)..(4)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"
 

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (16)..(16)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (18)..(18)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (18)..(18)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (21)..(21)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="His"

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (24)..(24)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (27)..(27)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (27)..(27)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (31)..(31)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="His"

<220>
<221> misc_feature
<222> (31)..(32)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (50)..(50)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (50)..(50)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (52)..(52)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (52)..(52)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (55)..(55)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (55)..(55)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (59)..(59)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (59)..(59)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (83)..(83)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (84)..(84)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (83)..(86)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (89)..(89)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (89)..(89)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (91)..(91)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (91)..(91)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (94)..(94)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (95)..(95)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (94)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (104)..(104)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (104)..(105)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (115)..(115)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (115)..(115)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (117)..(117)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (117..(117)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (125)..(125)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (125)..(125)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (130)..(130)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (130)..(130)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (132)..(132)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (132)..(133)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (137)..(137)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (137)..(137)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (141)..(141)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (141)..(141)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (143)..(143)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (143)..(143)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (153)..(153)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (153)..(153)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (157)..(157)
<223> /replace="His"

<220>
<221> misc_feature
<222> (157)..(157)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (164)..(164)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (164)..(164)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (181)..(181)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (181)..(181)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (190)..(190)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (190)..(190)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (206)..(206)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (206)..(206)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (213)..(213)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (213)..(213)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (215)..(215)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (215)..(215)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (217)..(217)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (217)..(217)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (220)..(220)
<223> /replace="Ile"

<220>
<221> misc_feature
<222> (220)..(220)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (223)..(223)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (225)..(227)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (236)..(236)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (236)..(236)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (244)..(244)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (245)..(245)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (244)..(245)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (249)..(249)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (250)..(250)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (249)..(250)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (253)..(253)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (254)..(254)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (253)..(254)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (258)..(258)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (258)..(258)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (267)..(267)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (268)..(268)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (269)..(269)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (270)..(270)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (271)..(271)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (267)..(271)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (274)..(274)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (278)..(278)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (278)..(278)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (281)..(281)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (282)..(282)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (283)..(283)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (284)..(284)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (281)..(284)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (289)..(289)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (289)..(289)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (293)..(293)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (294)..(294)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (295)..(295)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (296)..(296)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (293)..(297)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (300)..(300)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (301)..(301)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (300)..(301)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (309)..(309)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (309)..(309)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (312)..(312)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (313)..(313)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (312)..(313)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (317)..(317)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (318)..(318)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="His"

<220>
<221> misc_feature
<222> (317)..(319)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (322)..(322)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (321)..(322)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (333)..(333)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (333)..(333)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (339)..(339)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (339)..(339)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (341)..(341)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (341)..(341)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (343)..(343)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (344)..(344)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (343)..(344)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (358)..(358)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (359)..(359)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (358)..(359)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (363)..(363)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (363)..(363)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (369)..(369)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (369)..(369)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (372)..(372)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (373)..(373)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (374)..(374)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (375)..(375)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (377)..(377)
<223> /replace=" "

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace=" "

<220>
<221> VARIANT
<222> (379)..(379)
<223> /replace=" "

<220>
<221> misc_feature
<222> (372)..(379)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (385)..(385)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (386)..(386)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (385)..(386)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (392)..(392)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (392)..(392)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (401)..(401)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (401)..(401)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (409)..(409)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (409)..(409)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (419)..(419)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (419)..(419)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (422)..(422)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (423)..(423)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (424)..(424)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (421)..(424)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (440)..(440)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (440)..(440)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (443)..(443)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (443)..(443)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (445)..(445)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (446)..(446)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (447)..(447)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (445)..(447)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (450)..(450)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (451)..(451)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (450)..(451)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (464)..(464)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (464)..(464)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (466)..(466)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (466)..(466)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (474)..(474)
<223> /replace="His"

<220>
<221> misc_feature
<222> (474)..(474)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (477)..(477)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (477)..(477)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (485)..(485)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (485)..(485)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (487)..(487)
<223> /replace=" "

<220>
<221> VARIANT
<222> (488)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(497)
<223> /replace=" "

<220>
<221> VARIANT
<222> (498)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> VARIANT
<222> (518)..(518)
<223> /replace=" "

<220>
<221> misc_feature
<222> (487)..(518)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 24
Ala Ala Pro Phe Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Ile Gly Ile Thr Ala Leu Trp Ile Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Ala Gly Ala Asp Ala 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ala Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Ile Ser Arg Ile Phe 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Ser Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Asp Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Ile Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Ala Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Leu Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Pro Lys Glu Ile Pro Ser Leu Lys 
    370                 375                 380                 


Ser Lys Ile Asp Pro Ile Leu Ile Ala Arg Lys Asp Tyr Ala Tyr Gly 
385                 390                 395                 400 


Thr Gln His Asp Tyr Ile Asp His Ser Asp Ile Ile Gly Trp Thr Arg 
                405                 410                 415     


Glu Gly Val Ser Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr 
            420                 425                 430         


Asp Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala 
        435                 440                 445             


Gly Lys Val Phe Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Thr 
    450                 455                 460                 


Ile Asn Ser Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val 
465                 470                 475                 480 


Ser Ile Trp Val Pro Lys Lys Thr Thr Val Ser Thr Ile Ala Arg Pro 
                485                 490                 495     


Ile Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro 
            500                 505                 510         


Arg Leu Val Ala Trp Pro 
        515             


<210> 25
<211> 517
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (1)..(5)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (19)..(19)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (19)..(19)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace="His"

<220>
<221> misc_feature
<222> (22)..(23)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (25)..(25)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (29)..(29)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (28)..(29)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (37)..(37)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (35)..(37)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (53)..(53)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (54)..(54)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (53)..(54)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (60)..(60)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (60)..(60)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (83)..(83)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (83)..(83)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (87)..(87)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (85)..(87)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (93)..(93)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (92)..(93)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (95)..(95)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (95)..(95)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (106)..(106)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (105)..(106)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (116)..(116)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (116)..(116)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (118)..(118)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (118)..(118)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (125)..(125)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (126)..(126)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (125)..(126)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (134)..(134)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (134)..(134)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (136)..(136)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (136)..(136)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (138)..(138)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (138)..(138)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (154)..(154)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (154)..(154)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (169)..(169)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (169)..(169)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (175)..(175)
<223> /replace=" "

<220>
<221> misc_feature
<222> (174)..(175)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (183)..(183)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (215)..(215)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (215)..(215)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (222)..(222)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (222)..(222)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (228)..(229)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (246)..(246)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (247)..(247)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (246)..(247)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (251)..(251)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (251)..(251)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (256)..(256)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (260)..(260)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (260)..(260)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (263)..(263)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (263)..(263)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (269)..(269)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (270)..(270)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (269)..(270)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (273)..(273)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (273)..(274)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (276)..(276)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (276)..(276)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (280)..(280)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (284)..(284)
<223> /replace="Trp"

<220>
<221> VARIANT
<222> (285)..(285)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (286)..(286)
<223> /replace="His"

<220>
<221> misc_feature
<222> (284)..(286)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (291)..(291)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (291)..(291)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (295)..(295)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (296)..(296)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (295)..(297)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (299)..(299)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (299)..(299)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (306)..(306)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (306)..(306)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (311)..(311)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (311)..(311)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (313)..(313)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (314)..(314)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (315)..(315)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (313)..(315)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (320)..(320)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="His"

<220>
<221> misc_feature
<222> (319)..(321)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (323)..(323)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (324)..(324)
<223> /replace="His"

<220>
<221> misc_feature
<222> (323)..(324)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (335)..(335)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (335)..(335)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (337)..(337)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (338)..(338)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (337)..(338)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (341)..(341)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (341)..(341)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (346)..(346)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (346)..(346)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (355)..(355)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (356)..(356)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (355)..(356)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (360)..(360)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (361)..(361)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (360)..(361)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (365)..(365)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (365)..(365)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (376)..(376)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (378)..(378)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (391)..(391)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (391)..(391)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (394)..(394)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (395)..(395)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (394)..(395)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (400)..(400)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (400)..(400)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (402)..(402)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (402)..(402)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (408)..(408)
<223> /replace="His"

<220>
<221> VARIANT
<222> (409)..(409)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (408)..(409)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (418)..(418)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (418)..(418)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (420)..(420)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="His"

<220>
<221> misc_feature
<222> (420)..(421)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (423)..(423)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (423)..(423)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (428)..(428)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (428)..(428)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (434)..(434)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (434)..(434)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (437)..(437)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (437)..(437)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (446)..(446)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (446)..(446)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (449)..(449)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (449)..(449)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (452)..(452)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (452)..(452)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (460)..(460)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (460)..(460)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (471)..(471)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (471)..(471)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (473)..(473)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (473)..(473)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (484)..(484)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (485)..(485)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (484)..(485)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (486)..(486)
<223> /replace=" "

<220>
<221> VARIANT
<222> (487)..(488)
<223> /replace=" "

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> misc_feature
<222> (486)..(517)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 25
His Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Ser Ala Leu Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Ile Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Asn Ala Ala His Ala Ala Gly 
                85                  90                  95      


Ile Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Asn Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Ile Ser His Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Ala Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Ile His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Ala Phe Asp Met Arg Thr Ile Met Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Ser Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Phe Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln His Asn Ile Pro Ala Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Ile Ile Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Phe Val Gly Lys Asn His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Ile Thr Gly Asn Arg Ala Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Lys Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile 
                485                 490                 495     


Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg 
            500                 505                 510         


Leu Val Ala Trp Pro 
        515         


<210> 26
<211> 517
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (1)..(5)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (19)..(19)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (19)..(19)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace="His"

<220>
<221> misc_feature
<222> (22)..(23)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (25)..(25)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (29)..(29)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (28)..(29)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (37)..(37)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (35)..(37)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (53)..(53)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (54)..(54)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (53)..(54)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (60)..(60)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (60)..(60)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (87)..(87)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (85)..(87)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (90)..(90)
<223> /replace="His"

<220>
<221> misc_feature
<222> (90)..(90)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (93)..(93)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (94)..(95)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (92)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (106)..(106)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (105)..(106)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (116)..(116)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (116)..(116)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (118)..(118)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (118)..(118)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (125)..(125)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (126)..(126)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (125)..(126)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (134)..(134)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (134)..(134)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (136)..(136)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (136)..(136)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (138)..(138)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (138)..(138)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (154)..(154)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (154)..(154)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (169)..(169)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (169)..(169)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (172)..(172)
<223> /replace=" "

<220>
<221> VARIANT
<222> (173)..(173)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (175)..(175)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (172)..(175)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (183)..(183)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (215)..(215)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (215)..(215)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (219)..(219)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (219)..(219)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (222)..(222)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (222)..(222)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (228)..(228)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (246)..(246)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (247)..(247)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (246)..(247)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (255)..(255)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (255)..(256)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (260)..(260)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (260)..(260)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (263)..(263)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (263)..(263)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (269)..(269)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (270)..(270)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (269)..(270)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (273)..(273)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (273)..(274)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (276)..(276)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (276)..(276)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (280)..(280)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (284)..(284)
<223> /replace="Trp"

<220>
<221> VARIANT
<222> (285)..(285)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (286)..(286)
<223> /replace="His"

<220>
<221> misc_feature
<222> (284)..(286)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (291)..(291)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (291)..(291)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (295)..(295)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (296)..(296)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (295)..(297)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (299)..(299)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (299)..(299)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (302)..(302)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (302)..(302)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (306)..(306)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (306)..(306)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (310)..(310)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (311)..(311)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (310)..(311)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (314)..(314)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (315)..(315)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (314)..(315)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (320)..(320)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="His"

<220>
<221> misc_feature
<222> (319)..(321)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (323)..(323)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (324)..(324)
<223> /replace="His"

<220>
<221> misc_feature
<222> (323)..(324)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (335)..(335)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (335)..(335)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (338)..(338)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (338)..(338)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (341)..(341)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (341)..(341)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (345)..(345)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (346)..(346)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (345)..(346)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (355)..(355)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (355)..(355)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position" 

<220>
<221> VARIANT
<222> (360)..(360)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (361)..(361)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (360)..(361)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (365)..(365)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (365)..(365)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (376)..(376)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (378)..(378)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (391)..(391)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (391)..(391)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (394)..(394)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (395)..(395)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (394)..(395)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (405)..(405)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (405)..(405)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (408)..(408)
<223> /replace="His"

<220>
<221> VARIANT
<222> (409)..(409)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (408)..(409)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (418)..(418)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (418)..(418)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (420)..(420)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="His"

<220>
<221> misc_feature
<222> (420)..(421)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (423)..(423)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (423)..(423)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (428)..(428)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (428)..(428)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (437)..(437)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (437)..(437)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (444)..(444)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (444)..(444)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (446)..(446)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (446)..(446)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (449)..(449)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (449)..(449)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (459)..(459)
<223> /replace="Pro"

<220>
<221> VARIANT
<222> (460)..(460)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (459)..(460)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (471)..(471)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (471)..(471)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (473)..(473)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (473)..(473)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (484)..(484)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (484)..(484)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (486)..(486)
<223> /replace=" "

<220>
<221> VARIANT
<222> (487)..(488)
<223> /replace=" "

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> misc_feature
<222> (486)..(517)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 26
His Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Met Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Ala Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Gln Lys Leu Ser Arg 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Ser Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser His Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Ala Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Ala Phe Asp Met Arg Thr Leu Leu Thr Asn Thr Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Ser Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Phe Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln His Asn Ile Pro Ala Leu Lys Ala 
    370                 375                 380                 


Lys Ile Asp Pro Ile Leu Ile Ala Arg Arg Asp Phe Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Ile Ile Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Asn His Ala Gly 
        435                 440                 445             


Lys Val Phe His Asp Ile Thr Gly Asn Lys Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Ala Glu Phe Lys Val Asn Gly Gly Ser Val Ser 
465                 470                 475                 480 


Ile Trp Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile 
                485                 490                 495     


Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg 
            500                 505                 510         


Leu Val Ala Trp Pro 
        515         


<210> 27
<211> 517
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (1)..(5)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (19)..(19)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (19)..(19)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace="His"

<220>
<221> misc_feature
<222> (22)..(23)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (25)..(25)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (29)..(29)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (28)..(29)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (37)..(37)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (37)..(37)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (53)..(53)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (54)..(54)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (53)..(54)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (60)..(60)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (60)..(60)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (87)..(87)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (85)..(87)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (90)..(90)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (90)..(90)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (93)..(93)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (94)..(95)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (92)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (106)..(106)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (105)..(106)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (116)..(116)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (116)..(116)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (118)..(118)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (118)..(118)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (124)..(124)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (124)..(124)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (126)..(126)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (126)..(126)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (134)..(134)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (134)..(134)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (136)..(136)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (136)..(136)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (138)..(138)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (138)..(138)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (154)..(154)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (154)..(154)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (165)..(165)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (165)..(165)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (169)..(169)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (169)..(169)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (172)..(172)
<223> /replace=" "

<220>
<221> VARIANT
<222> (173)..(173)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (175)..(175)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (172)..(175)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (183)..(183)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (193)..(193)
<223> /replace="Ile"

<220>
<221> misc_feature
<222> (193)..(193)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (215)..(215)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (215)..(215)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (222)..(222)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (222)..(222)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (228)..(228)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (246)..(246)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (247)..(247)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (246)..(247)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (255)..(255)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (255)..(256)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (263)..(263)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (263)..(263)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (269)..(269)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (270)..(270)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (269)..(270)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (273)..(273)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (273)..(274)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (276)..(276)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (276)..(276)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (280)..(280)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (283)..(283)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (284)..(284)
<223> /replace="Trp"

<220>
<221> VARIANT
<222> (285)..(285)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (286)..(286)
<223> /replace="His"

<220>
<221> misc_feature
<222> (283)..(286)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (291)..(291)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (291)..(291)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (295)..(295)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (296)..(296)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (295)..(297)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (299)..(299)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (299)..(299)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (302)..(302)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (302)..(302)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (306)..(306)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (306)..(306)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (311)..(311)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (311)..(311)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (314)..(314)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (315)..(315)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (314)..(315)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (320)..(320)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="His"

<220>
<221> misc_feature
<222> (319)..(321)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (323)..(323)
<223> /replace="Ile"

<220>
<221> VARIANT
<222> (324)..(324)
<223> /replace="His"

<220>
<221> misc_feature
<222> (323)..(324)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (335)..(335)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (335)..(335)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (338)..(338)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (338)..(338)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (341)..(341)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (341)..(341)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (345)..(345)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (346)..(346)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (345)..(346)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (355)..(355)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (355)..(355)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (360)..(360)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (361)..(361)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (360)..(361)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (365)..(365)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (365)..(365)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (376)..(376)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (378)..(378)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (391)..(391)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (391)..(391)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (394)..(394)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (395)..(395)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (394)..(395)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (405)..(405)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (405)..(405)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (408)..(408)
<223> /replace="His"

<220>
<221> misc_feature
<222> (408)..(408)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (418)..(418)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (418)..(418)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (420)..(420)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="His"

<220>
<221> misc_feature
<222> (420)..(421)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (423)..(423)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (423)..(423)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (428)..(428)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (428)..(428)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (437)..(437)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (437)..(437)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (445)..(445)
<223> /replace="His"

<220>
<221> VARIANT
<222> (446)..(446)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (445)..(446)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (449)..(449)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (449)..(449)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (452)..(452)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (452)..(452)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (460)..(460)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (460)..(460)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (471)..(471)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (471)..(471)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (473)..(473)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (473)..(473)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (484)..(484)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (485)..(485)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (486)..(486)
<223> /replace=" "

<220>
<221> VARIANT
<222> (487)..(488)
<223> /replace=" "

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(495)
<223> /replace=" "

<220>
<221> VARIANT
<222> (496)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace=" "

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace=" "

<220>
<221> misc_feature
<222> (484)..(517)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 27
His Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His 
1               5                   10                  15      


Leu Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn 
            20                  25                  30          


Asn Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Ile Pro Pro Ala Trp 
        35                  40                  45              


Lys Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr 
    50                  55                  60                  


Asp Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly 
65                  70                  75                  80  


Thr Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly 
                85                  90                  95      


Ile Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp 
            100                 105                 110         


Gly Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn 
        115                 120                 125             


Gln Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp 
    130                 135                 140                 


Phe Pro Gly Arg Gly Asn Thr His Ser Ser Phe Lys Trp Arg Trp Tyr 
145                 150                 155                 160 


His Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Gln Lys Leu Ser Lys 
                165                 170                 175     


Ile Tyr Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp 
            180                 185                 190         


Thr Glu Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Ile Asp Met 
        195                 200                 205             


Asp His Pro Glu Val Ile Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr 
    210                 215                 220                 


Val Asn Thr Thr Asn Ile Asp Gly Phe Arg Ile Asp Ala Val Lys His 
225                 230                 235                 240 


Ile Lys Phe Ser Phe Phe Pro Asp Trp Leu Ser His Val Arg Ser Gln 
                245                 250                 255     


Thr Gly Lys Pro Leu Phe Thr Val Ala Glu Phe Trp Ser Tyr Asp Ile 
            260                 265                 270         


Asn Lys Ile His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu 
        275                 280                 285             


Phe Asp Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly 
    290                 295                 300                 


Gly Ala Phe Asp Met Arg Thr Ile Leu Thr Asn Ser Leu Met Lys Asp 
305                 310                 315                 320 


Gln Pro Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Ser Glu Pro 
                325                 330                 335     


Gly Gln Ala Leu Gln Ser Phe Val Asp Pro Trp Phe Lys Pro Leu Ala 
            340                 345                 350         


Tyr Ala Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr 
        355                 360                 365             


Gly Asp Tyr Tyr Gly Ile Pro Gln His Asn Ile Pro Ser Leu Lys Ser 
    370                 375                 380                 


Lys Ile Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr 
385                 390                 395                 400 


Gln His Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu 
                405                 410                 415     


Gly Val Ser Glu Lys Pro Gly Ser Gly Leu Ala Ala Ile Ile Ser Asp 
            420                 425                 430         


Gly Pro Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly 
        435                 440                 445             


Lys Val Phe Tyr Asp Ile Thr Gly Asn Arg Ser Asp Thr Val Thr Ile 
    450                 455                 460                 


Asn Ala Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ala Val Ser 
465                 470                 475                 480 


Val Trp Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile 
                485                 490                 495     


Thr Thr Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg 
            500                 505                 510         


Leu Val Ala Trp Pro 
        515 


<210> 28
<211> 515
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (1)..(4)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (17)..(17)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (18)..(18)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (17)..(18)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (21)..(21)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="His"

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (24)..(24)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (27)..(27)
<223> /replace="His"

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (27)..(28)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (31)..(32)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (31)..(32)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (35)..(36)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (50)..(50)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (50)..(50)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (52)..(52)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (52)..(52)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (59)..(59)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (59)..(59)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (84)..(84)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (84)..(86)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (89)..(89)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (89)..(89)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (91)..(91)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (91)..(92)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (94)..(94)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (95)..(95)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (94)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (104)..(104)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (104)..(105)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (108)..(108)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (108)..(108)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (112)..(112)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (112)..(112)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (115)..(115)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (115)..(115)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (117)..(117)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (117)..(117)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (120)..(120)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (120)..(120)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (125)..(125)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (125)..(125)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (127)..(127)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (127)..(127)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (133)..(133)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (135)..(135)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (135)..(135)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (137)..(137)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (137)..(137)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (141)..(141)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (141)..(141)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (145)..(145)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (145)..(145)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (148)..(148)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (148)..(148)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (150)..(150)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (150)..(150)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (153)..(153)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (153)..(153)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (162)..(162)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (162)..(162)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (168)..(168)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (169)..(169)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (170)..(170)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (171)..(171)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (172)..(172)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (173)..(173)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="His"

<220>
<221> misc_feature
<222> (168)..(174)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (179)..(179)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (180)..(180)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (181)..(181)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (182)..(182)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace=" "

<220>
<221> VARIANT
<222> (184)..(184)
<223> /replace=" "

<220>
<221> misc_feature
<222> (179)..(184)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (186)..(186)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (186)..(186)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (188)..(188)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (188)..(188)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (191)..(191)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (191)..(191)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (201)..(201)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (201)..(201)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (203)..(203)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (203)..(203)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (206)..(206)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (207)..(207)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (206)..(207)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (213)..(213)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (212)..(213)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (217)..(217)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (217)..(217)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (220)..(220)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (220)..(220)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (223)..(227)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (240)..(240)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (240)..(240)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (242)..(242)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (242)..(242)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (244)..(244)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (245)..(245)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (244)..(245)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (249)..(249)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (249)..(249)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (251)..(251)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (251)..(251)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (253)..(253)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (254)..(254)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (255)..(255)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (257)..(257)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (258)..(258)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (253)..(258)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (261)..(261)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (261)..(261)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (267)..(267)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (268)..(268)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (267)..(268)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (271)..(271)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (272)..(272)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (271)..(272)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (275)..(275)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (274)..(275)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (278)..(278)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (279)..(279)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (278)..(280)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (282)..(282)
<223> /replace="Trp"

<220>
<221> VARIANT
<222> (283)..(283)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (282)..(283)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (289)..(289)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (289)..(289)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (292)..(292)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (293)..(293)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (294)..(294)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (292)..(294)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (297)..(297)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (300)..(300)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (301)..(301)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (300)..(301)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (309)..(309)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (309)..(309)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (312)..(312)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (313)..(313)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (312)..(313)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (317)..(317)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (318)..(318)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="His"

<220>
<221> misc_feature
<222> (317)..(319)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (322)..(322)
<223> /replace="His"

<220>
<221> misc_feature
<222> (321)..(322)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (333)..(333)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (333)..(333)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (336)..(336)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (336)..(336)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (339)..(339)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (339)..(339)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (343)..(343)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (344)..(344)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (343)..(344)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (353)..(353)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (353)..(353)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (358)..(358)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (359)..(359)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (358)..(359)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (363)..(363)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (363)..(363)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (375)..(375)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (375)..(375)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (378)..(378)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (380)..(380)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (380)..(380)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (382)..(382)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (383)..(383)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (382)..(383)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (386)..(386)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (386)..(386)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (389)..(389)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (389)..(389)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (392)..(392)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (393)..(393)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (392)..(393)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (403)..(403)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (403)..(403)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (406)..(406)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (406)..(406)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (416)..(416)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (416)..(416)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (418)..(418)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (418)..(418)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (421)..(421)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (426)..(426)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (426)..(426)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (430)..(430)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (430)..(430)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (444)..(444)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (444)..(444)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (447)..(447)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (448)..(448)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (447)..(448)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (450)..(450)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (450)..(450)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (456)..(456)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (457)..(457)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (458)..(458)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (456)..(458)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (464)..(464)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (464)..(464)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (471)..(471)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (472)..(472)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (471)..(472)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (482)..(482)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (483)..(483)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (484)..(484)
<223> /replace=" "

<220>
<221> VARIANT
<222> (485)..(486)
<223> /replace=" "

<220>
<221> VARIANT
<222> (487)..(487)
<223> /replace=" "

<220>
<221> VARIANT
<222> (488)..(488)
<223> /replace=" "

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(497)
<223> /replace=" "

<220>
<221> VARIANT
<222> (498)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> misc_feature
<222> (482)..(515)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 28
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Ile 
                85                  90                  95      


Asn Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Asp Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Phe His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Phe 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Leu Tyr Ala Asp Ile Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Phe Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Ile Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser His Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Ile Leu Thr Asn Ser Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Asn Tyr Asn Ile Pro Ala Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Ser Glu Lys Pro Gly Ser Gly Leu Ala Ala Ile Ile Ser Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Ser Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515


<210> 29
<211> 515
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (1)..(4)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (17)..(17)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (18)..(18)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (17)..(18)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (21)..(21)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="His"

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (24)..(24)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (27)..(27)
<223> /replace="His"

<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (27)..(28)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (31)..(31)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (31)..(32)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (35)..(36)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (50)..(50)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (50)..(50)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (52)..(52)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (52)..(52)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (59)..(59)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (59)..(59)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (84)..(84)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (85)..(85)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (86)..(86)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (84)..(86)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (89)..(89)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (89)..(89)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (91)..(91)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (91)..(92)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (94)..(94)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (95)..(95)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (94)..(95)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (104)..(104)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (104)..(105)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (108)..(108)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (108)..(108)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (112)..(112)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (112)..(112)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (115)..(115)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (115)..(115)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (117)..(117)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (117)..(117)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (120)..(120)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (120)..(120)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (125)..(125)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (125)..(125)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (127)..(127)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (127)..(127)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (133)..(133)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (135)..(135)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (135)..(135)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (137)..(137)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (137)..(137)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (141)..(141)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (141)..(141)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (148)..(148)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (148)..(148)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (150)..(150)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (150)..(150)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (153)..(153)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (153)..(153)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (162)..(162)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (162)..(162)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (168)..(168)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (169)..(169)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (170)..(170)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (171)..(171)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (172)..(172)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (173)..(173)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="His"

<220>
<221> misc_feature
<222> (168)..(174)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (179)..(179)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (180)..(180)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (181)..(181)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (182)..(182)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (183)..(183)
<223> /replace=" "

<220>
<221> VARIANT
<222> (184)..(184)
<223> /replace=" "

<220>
<221> misc_feature
<222> (179)..(184)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (186)..(186)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (186)..(186)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (188)..(188)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (188)..(188)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (191)..(191)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (191)..(191)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (201)..(201)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (201)..(201)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (203)..(203)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (203)..(203)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (206)..(206)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (207)..(207)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (206)..(207)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (213)..(213)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (212)..(213)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (217)..(217)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (217)..(217)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (220)..(220)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (220)..(220)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Leu"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (223)..(227)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (240)..(240)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (240)..(240)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (242)..(242)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (242)..(242)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (244)..(244)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (245)..(245)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (244)..(245)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (249)..(249)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (249)..(249)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (251)..(251)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (251)..(251)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (254)..(254)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (255)..(255)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (256)..(256)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (257)..(257)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (258)..(258)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (254)..(258)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (261)..(261)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (261)..(261)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (267)..(267)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (268)..(268)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (267)..(268)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (271)..(271)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (272)..(272)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (271)..(272)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (274)..(274)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (275)..(275)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (274)..(275)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (278)..(278)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (279)..(279)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (280)..(280)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (278)..(280)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (282)..(282)
<223> /replace="Trp"

<220>
<221> VARIANT
<222> (283)..(283)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (282)..(283)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (289)..(289)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (289)..(289)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (292)..(292)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (293)..(293)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (294)..(294)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (292)..(294)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (297)..(297)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (297)..(297)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (301)..(301)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (301)..(301)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (309)..(309)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (309)..(309)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (312)..(312)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (313)..(313)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (312)..(313)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (317)..(317)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (318)..(318)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (319)..(319)
<223> /replace="His"

<220>
<221> misc_feature
<222> (317)..(319)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (321)..(321)
<223> /replace="Ile"

<220>
<221> VARIANT
<222> (322)..(322)
<223> /replace="His"

<220>
<221> misc_feature
<222> (321)..(322)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (333)..(333)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (333)..(333)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (336)..(336)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (336)..(336)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (339)..(339)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (339)..(339)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (343)..(343)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (344)..(344)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (343)..(344)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (353)..(353)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (353)..(353)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (358)..(358)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (359)..(359)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (358)..(359)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (363)..(363)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (363)..(363)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (375)..(375)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (375)..(375)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (378)..(378)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (380)..(380)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (380)..(380)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (382)..(382)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (383)..(383)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (382)..(383)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (386)..(386)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (386)..(386)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (389)..(389)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (389)..(389)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (392)..(392)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (393)..(393)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (392)..(393)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (403)..(403)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (403)..(403)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (406)..(406)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (406)..(406)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (416)..(416)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (416)..(416)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (418)..(418)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (418)..(418)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (421)..(421)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (421)..(421)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (426)..(426)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (426)..(426)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (430)..(430)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (430)..(430)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (442)..(442)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (442)..(442)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (447)..(447)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (448)..(448)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (447)..(448)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (450)..(450)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (450)..(450)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (456)..(456)
<223> /replace="His"

<220>
<221> misc_feature
<222> (456)..(456)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (458)..(458)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (458)..(458)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (464)..(464)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (464)..(464)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (471)..(471)
<223> /replace="Phe"

<220>
<221> VARIANT
<222> (472)..(472)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (471)..(472)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (482)..(482)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (483)..(483)
<223> /replace="Gln"

<220>
<221> VARIANT
<222> (484)..(484)
<223> /replace=" "

<220>
<221> VARIANT
<222> (485)..(486)
<223> /replace=" "

<220>
<221> VARIANT
<222> (487)..(487)
<223> /replace=" "

<220>
<221> VARIANT
<222> (488)..(488)
<223> /replace=" "

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(497)
<223> /replace=" "

<220>
<221> VARIANT
<222> (498)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> misc_feature
<222> (482)..(515)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 29
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp His Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Leu Ala Asn Asp Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Ile Trp Ile Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ala Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Ile 
                85                  90                  95      


Asn Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Asp Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Phe His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Phe 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Leu Tyr Ala Asp Ile Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Phe Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Ile Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser His Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Ile Leu Thr Asn Ser Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Asn Tyr Asn Ile Pro Ala Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Ser Glu Lys Pro Gly Ser Gly Leu Ala Ala Ile Ile Ser Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ala Asp Ser Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515    


<210> 30
<211> 515
<212> PRT
<213> Artificial sequence

<220>
<221> source
<223> /note="Description of artificial sequence: Synthetic 
      consensus sequence"


<220>
<221> VARIANT
<222> (180)..(180)
<223> /replace=" "

<220>
<221> VARIANT
<222> (181)..(181)
<223> /replace=" "

<220>
<221> misc_feature
<222> (180)..(181)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (193)..(193)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (193)..(193)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (416)..(416)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (416)..(416)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (489)..(489)
<223> /replace=" "

<220>
<221> VARIANT
<222> (490)..(490)
<223> /replace=" "

<220>
<221> VARIANT
<222> (491)..(491)
<223> /replace=" "

<220>
<221> VARIANT
<222> (492)..(492)
<223> /replace=" "

<220>
<221> VARIANT
<222> (493)..(493)
<223> /replace=" "

<220>
<221> VARIANT
<222> (494)..(494)
<223> /replace=" "

<220>
<221> VARIANT
<222> (495)..(496)
<223> /replace=" "

<220>
<221> VARIANT
<222> (497)..(497)
<223> /replace=" "

<220>
<221> VARIANT
<222> (498)..(498)
<223> /replace=" "

<220>
<221> VARIANT
<222> (499)..(499)
<223> /replace=" "

<220>
<221> VARIANT
<222> (500)..(500)
<223> /replace=" "

<220>
<221> VARIANT
<222> (501)..(501)
<223> /replace=" "

<220>
<221> VARIANT
<222> (502)..(502)
<223> /replace=" "

<220>
<221> VARIANT
<222> (503)..(503)
<223> /replace=" "

<220>
<221> VARIANT
<222> (504)..(504)
<223> /replace=" "

<220>
<221> VARIANT
<222> (505)..(505)
<223> /replace=" "

<220>
<221> VARIANT
<222> (506)..(506)
<223> /replace=" "

<220>
<221> VARIANT
<222> (507)..(507)
<223> /replace=" "

<220>
<221> VARIANT
<222> (508)..(508)
<223> /replace=" "

<220>
<221> VARIANT
<222> (509)..(509)
<223> /replace=" "

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace=" "

<220>
<221> VARIANT
<222> (511)..(511)
<223> /replace=" "

<220>
<221> VARIANT
<222> (512)..(512)
<223> /replace=" "

<220>
<221> VARIANT
<222> (513)..(513)
<223> /replace=" "

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace=" "

<220>
<221> VARIANT
<222> (515)..(515)
<223> /replace=" "

<220>
<221> misc_feature
<222> (489)..(515)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<400> 30
Ala Ala Pro Phe Asn Gly Thr Met Met Gln Tyr Phe Glu Trp Tyr Leu 
1               5                   10                  15      


Pro Asp Asp Gly Thr Leu Trp Thr Lys Val Ala Asn Glu Ala Asn Asn 
            20                  25                  30          


Leu Ser Ser Leu Gly Ile Thr Ala Leu Trp Leu Pro Pro Ala Tyr Lys 
        35                  40                  45              


Gly Thr Ser Arg Ser Asp Val Gly Tyr Gly Val Tyr Asp Leu Tyr Asp 
    50                  55                  60                  


Leu Gly Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr 
65                  70                  75                  80  


Lys Ala Gln Tyr Leu Gln Ala Ile Gln Ala Ala His Ala Ala Gly Met 
                85                  90                  95      


Gln Val Tyr Ala Asp Val Val Phe Asp His Lys Gly Gly Ala Asp Gly 
            100                 105                 110         


Thr Glu Trp Val Asp Ala Val Glu Val Asn Pro Ser Asp Arg Asn Gln 
        115                 120                 125             


Glu Ile Ser Gly Thr Tyr Gln Ile Gln Ala Trp Thr Lys Phe Asp Phe 
    130                 135                 140                 


Pro Gly Arg Gly Asn Thr Tyr Ser Ser Phe Lys Trp Arg Trp Tyr His 
145                 150                 155                 160 


Phe Asp Gly Val Asp Trp Asp Glu Ser Arg Lys Leu Ser Arg Ile Tyr 
                165                 170                 175     


Lys Phe Arg Gly Ile Gly Lys Ala Trp Asp Trp Glu Val Asp Thr Glu 
            180                 185                 190         


Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Met Asp His 
        195                 200                 205             


Pro Glu Val Val Thr Glu Leu Lys Asn Trp Gly Lys Trp Tyr Val Asn 
    210                 215                 220                 


Thr Thr Asn Ile Asp Gly Phe Arg Leu Asp Ala Val Lys His Ile Lys 
225                 230                 235                 240 


Phe Ser Phe Phe Pro Asp Trp Leu Ser Tyr Val Arg Ser Gln Thr Gly 
                245                 250                 255     


Lys Pro Leu Phe Thr Val Gly Glu Tyr Trp Ser Tyr Asp Ile Asn Lys 
            260                 265                 270         


Leu His Asn Tyr Ile Thr Lys Thr Asn Gly Thr Met Ser Leu Phe Asp 
        275                 280                 285             


Ala Pro Leu His Asn Lys Phe Tyr Thr Ala Ser Lys Ser Gly Gly Ala 
    290                 295                 300                 


Phe Asp Met Arg Thr Leu Met Thr Asn Thr Leu Met Lys Asp Gln Pro 
305                 310                 315                 320 


Thr Leu Ala Val Thr Phe Val Asp Asn His Asp Thr Glu Pro Gly Gln 
                325                 330                 335     


Ala Leu Gln Ser Trp Val Asp Pro Trp Phe Lys Pro Leu Ala Tyr Ala 
            340                 345                 350         


Phe Ile Leu Thr Arg Gln Glu Gly Tyr Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             


Tyr Tyr Gly Ile Pro Gln Tyr Asn Ile Pro Ser Leu Lys Ser Lys Ile 
    370                 375                 380                 


Asp Pro Leu Leu Ile Ala Arg Arg Asp Tyr Ala Tyr Gly Thr Gln His 
385                 390                 395                 400 


Asp Tyr Leu Asp His Ser Asp Ile Ile Gly Trp Thr Arg Glu Gly Val 
                405                 410                 415     


Thr Glu Lys Pro Gly Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro 
            420                 425                 430         


Gly Gly Ser Lys Trp Met Tyr Val Gly Lys Gln His Ala Gly Lys Val 
        435                 440                 445             


Phe Tyr Asp Leu Thr Gly Asn Arg Ser Asp Thr Val Thr Ile Asn Ser 
    450                 455                 460                 


Asp Gly Trp Gly Glu Phe Lys Val Asn Gly Gly Ser Val Ser Val Trp 
465                 470                 475                 480 


Val Pro Arg Lys Thr Thr Val Ser Thr Ile Ala Arg Pro Ile Thr Thr 
                485                 490                 495     


Arg Pro Trp Thr Gly Glu Phe Val Arg Trp Thr Glu Pro Arg Leu Val 
            500                 505                 510         


Ala Trp Pro 
        515 


<210> 31
<211> 413
<212> PRT
<213> Buttiauxella sp.

<400> 31
Asn Asp Thr Pro Ala Ser Gly Tyr Gln Val Glu Lys Val Val Ile Leu 
1               5                   10                  15      


Ser Arg His Gly Val Arg Ala Pro Thr Lys Met Thr Gln Thr Met Arg 
            20                  25                  30          


Asp Val Thr Pro Asn Thr Trp Pro Glu Trp Pro Val Lys Leu Gly Tyr 
        35                  40                  45              


Ile Thr Pro Arg Gly Glu His Leu Ile Ser Leu Met Gly Gly Phe Tyr 
    50                  55                  60                  


Arg Gln Lys Phe Gln Gln Gln Gly Ile Leu Ser Gln Gly Ser Cys Pro 
65                  70                  75                  80  


Thr Pro Asn Ser Ile Tyr Val Trp Ala Asp Val Asp Gln Arg Thr Leu 
                85                  90                  95      


Lys Thr Gly Glu Ala Phe Leu Ala Gly Leu Ala Pro Gln Cys Gly Leu 
            100                 105                 110         


Thr Ile His His Gln Gln Asn Leu Glu Lys Ala Asp Pro Leu Phe His 
        115                 120                 125             


Pro Val Lys Ala Gly Thr Cys Ser Met Asp Lys Thr Gln Val Gln Gln 
    130                 135                 140                 


Ala Val Glu Lys Glu Ala Gln Thr Pro Ile Asp Asn Leu Asn Gln His 
145                 150                 155                 160 


Tyr Ile Pro Phe Leu Ala Leu Met Asn Thr Thr Leu Asn Phe Ser Thr 
                165                 170                 175     


Ser Ala Trp Cys Gln Lys His Ser Ala Asp Lys Ser Cys Asp Leu Gly 
            180                 185                 190         


Leu Ser Met Pro Ser Lys Leu Ser Ile Lys Asp Asn Gly Asn Lys Val 
        195                 200                 205             


Ala Leu Asp Gly Ala Ile Gly Leu Ser Ser Thr Leu Ala Glu Ile Phe 
    210                 215                 220                 


Leu Leu Glu Tyr Ala Gln Gly Met Pro Gln Ala Ala Trp Gly Asn Ile 
225                 230                 235                 240 


His Ser Glu Gln Glu Trp Ala Ser Leu Leu Lys Leu His Asn Val Gln 
                245                 250                 255     


Phe Asp Leu Met Ala Arg Thr Pro Tyr Ile Ala Arg His Asn Gly Thr 
            260                 265                 270         


Pro Leu Leu Gln Ala Ile Ser Asn Ala Leu Asn Pro Asn Ala Thr Glu 
        275                 280                 285             


Ser Lys Leu Pro Asp Ile Ser Pro Asp Asn Lys Ile Leu Phe Ile Ala 
    290                 295                 300                 


Gly His Asp Thr Asn Ile Ala Asn Ile Ala Gly Met Leu Asn Met Arg 
305                 310                 315                 320 


Trp Thr Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Ala Leu 
                325                 330                 335     


Val Phe Glu Arg Leu Ala Asp Lys Ser Gly Lys Gln Tyr Val Ser Val 
            340                 345                 350         


Ser Met Val Tyr Gln Thr Leu Glu Gln Leu Arg Ser Gln Thr Pro Leu 
        355                 360                 365             


Ser Leu Asn Gln Pro Ala Gly Ser Val Gln Leu Lys Ile Pro Gly Cys 
    370                 375                 380                 


Asn Asp Gln Thr Ala Glu Gly Tyr Cys Pro Leu Ser Thr Phe Thr Arg 
385                 390                 395                 400 


Val Val Ser Gln Ser Val Glu Pro Gly Cys Gln Leu Gln 
                405                 410             




